UMIA, Iran—Hempseed may offer women who have had their ovaries removed via improving post-ovariectomy complications, according to current research (Methods Find Exp Clin Pharmacol. 2010 Sep;32(7):467-73). Cannabis sativa L. seed (aka hempseed) has been used for the treatment of various gynecological diseases in traditional medicine. The potential of this plant to protect against complications of menopause has been raised, but rarely studied. Therefore, 20 female rats were divided into five groups: sham-operated (sham), ovariectomized (OVX) and three other ovariectomized groups: HST1 percent, HST2 percent and HST10 percent, which received 1-percent, 2-percent and 10-percent hempseed, respectively, in their diet for three weeks. The effects of hempseed on plasma lipid and lipoprotein profiles, estradiol and calcium levels were evaluated. Rats were tested for behavioral changes using the forced swimming test.
Ovariectomy, independent of the type of diet, caused elevation of plasma calcium, total cholesterol and high-density lipoprotein (HDL) cholesterol levels, while hempseed modified. Plasma estradiol levels were significantly lower in the OVX group compared to other groups. The swimming times for the OVX and sham groups were significantly shorter than the HSD10-percent group. All hempseed-treated groups were less anxious and showed significant declines in fecal boli compared to the sham group. The exploratory diving percent decreased in the HST10-percent group compared with other groups.